PPAR-γin the Cardiovascular System
نویسندگان
چکیده
منابع مشابه
PPAR-γ in the Cardiovascular System
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), an essential transcriptional mediator of adipogenesis, lipid metabolism, insulin sensitivity, and glucose homeostasis, is increasingly recognized as a key player in inflammatory cells and in cardiovascular diseases (CVD) such as hypertension, cardiac hypertrophy, congestive heart failure, and atherosclerosis. PPAR-gamma agonists, th...
متن کاملPPAR in Cardiovascular Disorders
1Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow 125315, Russia 2Institute for Atherosclerosis Research, Skolkovo Innovation Center, Moscow 121609, Russia 3Laboratory of Lipoproteins and Atherosclerosis, Baker Heart Research and Diabetes Institute, Melbourne, VIC 3004, Australia 4Department of Development and Regeneration, Ka...
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Peroxisome proliferators activated receptors (PPARs) are ligand-activated nuclear transcription factors that play important roles in lipid and glucose homeostasis. To the extent that PPAR agonists improve diabetic dyslipidaemia and insulin resistance, these agents have been considered to reduce cardiovascular risk. However, data from murine models suggests that PPAR agonists also have independe...
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Cardiovascular disease is one of the leading causes of death in the United States. Studying the pathogenesis of cardiovascular disease is, therefore, essential for the possible alleviation of such cases. Further knowledge could lead to more effective drug treatment. Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a nuclear receptor found in vascular-associated cells such as endothe...
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ژورنال
عنوان ژورنال: PPAR Research
سال: 2008
ISSN: 1687-4757,1687-4765
DOI: 10.1155/2008/745804